Biomaterials

Our group is a leading research laboratory for the study of biomaterials including their structure, properties and biomedical applications. Past and present accomplishments of this lab include contact and intraocular lenses, non-thrombogenic materials, materials for articular cartilage, biohydrogels and biointerfacial phenomena.

We have investigated the surface properties of hydrogels in relation to medical applications and applied such systems to the development of materials for articular cartilage, vocal cords, contact lenses, artificial kidney membranes, and artificial organs in general. We are working on the development of biomedical surfaces for a portable artificial kidney and for systems to treat thrombotic effects through the use of streptokinase form fibrinolytic enzyme-immobilized microparticles. We have shown that diffusional effects play an important role in protein adsorption on polymeric surfaces for biomedical applications.

We are developing new biomaterials based on methacrylates, acrylates, poly(vinyl alcohol) and poly(ethylene glycol). Our research group has shown that the pH-sensitivity of many of these systems can be used to develop intelligent biomedical devices and biosensors.

Related publications

H. Bodugoz, O. Güven and N. A. Peppas, “Glucose Recognition Capabilities of HEMA-based Hydrogels Containing PEG Chains”, J. Appl. Polym. Sci., 103, 432-441 (2007). [PDF Reprint]

S. Seidlits and N.A. Peppas, “Star Polymers and Dendrimers in Nanotechnology and Drug Delivery” in N.A. Peppas, J.Z. Hilt and J.B. Thomas, eds, Nanotechnology in Therapeutics: Current Technology and Applications, 317-348, Horizon Press, Norfolk, UK, 2007.

K. M. Wood, G. Stone and N. A. Peppas, “Lectin Functionalized Complexation Hydrogels for Oral Protein Delivery”, J. Controlled Rel., 116, 66-68 (2006). [PDF Reprint]

N.A. Peppas, J.Z. Hilt, A. Khademhosseini and R. Langer, “Hydrogels in Biology and Medicine: From Fundamentals to Bionanotechnology”, Adv. Mater., 18, 1345-1360 (2006). [PDF Reprint]

K. Podual and N. A. Peppas, “Relaxational Behavior and Swelling-pH Master Curves of Poly(diethylaminoethyl methacrylate-g-ethylene glycol) Hydrogels”, Polym. Intern., 54, 581-593 (2005). [PDF Reprint]

E. Oral and N.A. Peppas, “Responsive and Recognitive Hydrogels Using Star Polymers,” J. Biomed. Mater. Res., 68A, 439-447 (2004). [PDF Reprint]

A.C. Foss, T. Goto, M. Morishita and N.A. Peppas, “Development of Acrylic-Based Copolymers for Oral Insulin Delivery,” Europ. J. Pharm. Biopharmac., 57, 163-169 (2004). [PDF Reprint]

B. Kim, K. La Flamme and N.A. Peppas, “Dynamic Swelling Behavior of pH-Sensitive Anionic Hydrogels Used for Protein Delivery,” J. Appl. Polym. Sci., 89, 1606-1613 (2003). [PDF Reprint]

S. Baumgartner, J. Kristl and N.A. Peppas, “Network Structure of Cellulose Ethers Used in Pharmaceutical Applications during Swellling and at Equilibrium,” Pharm. Res., 19, 1084-1090 (2002). [PDF Reprint]

M. Torres-Lugo and N.A. Peppas, “Transmucosal Delivery Systems for Calcitonin: A Review,” Biomaterials, 21, 1191-1196 (2000). [PDF Reprint]

R. Langer and N.A. Peppas, “Advances in Biomaterials, Drug Delivery, and Bionanotechnology”, AIChE J., 49, 2990-3006 (2003). [PDF Reprint]

N.A. Peppas and J.J. Sahlin, "Hydrogels as Muco- and Bioadhesive Materials: A Review," Biomaterials, 17, 1553-1561 (1996). [PDF Reprint]

R.A. Scott and N.A. Peppas, “Highly Crosslinked, PEG-Containing Copolymers for Sustained Solute Delivery,” Biomaterials, 20, 1371-1380 (1999). [PDF Reprint]

B. Kim and N.A. Peppas, “Synthesis and Characterization of pH-Sensitive Glycopolymers for Oral Drug Delivery Systems,” J. Biomater. Sci., Polym. Ed., 13, 1271-1281 (2002). [PDF Reprint]

J. Zhang and N.A. Peppas, “Morphology of poly(methacrylic acid)/Poly(N-isopropyl acrylamide) Interpenetrating Polymeric Networks,” J. Biomat. Sci., Polym. Ed., 13, 511-525 (2002). [PDF Reprint]

A.M. Lowman and N.A. Peppas, "Analysis of the Complexation/Decomplexation Phenomena in Graft Copolymer Networks," Macromolecules , 30, 4959-4965 (1997). [PDF Reprint]

N.A. Peppas, K.B. Keys, M. Torres-Lugo and A.M. Lowman, “Poly(ethylene glycol)-containing Hydrogels in Drug Delivery,” J. Controlled Release, 62, 81-87(1999). [PDF Reprint]

A.M. Lowman and N.A. Peppas, “Solute Transport Analysis in pH-Responsive, Complexing Hydrogels of Poly(Methacrylic Acid-g-Ethylene Glycol),” J. Biomat. Sci., Polym. Ed., 10, 999-1009 (1999). [PDF Reprint]

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