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Biographical Summary | Patents | Awards and Honors | 
Endowed/Honorary Lectureships | Career Achievements
Editorial Boards | Professional Societies and Positions Held | Extracurricular Activities 

Biographical Summary

Nicholas A. Peppas is the Fletcher Pratt Chaired Professor of Chemical Engineering, Biomedical Engineering and Pharmacy at the University of Texas at Austin. He is a world leader in biomaterials, controlled drug delivery, biomaterials and bionanotechnology. He received a Dipl. Eng. from NTU Athens (1971) and a Sc. D. from MIT (1973).

Dr Peppas has published more than 1,025 refereed publications, 350 proceedings and 320 abstracts, and is the inventor of 35 US and international patents.  He is the coauthor or coeditor of 31 books and volumes, including the classic, three-volume Hydrogels in Medicine and Pharmacy (CRC Press, 1987), a standard reference in the field of biomaterials with more than 3,000 citations, the monograph Pulsatile Drug Delivery, (WSGS, Stuttgart, 1993), two books on Biopolymers (Springer, 1994), the monograph Physicochemical and Cellular Foundations of Biomaterials Science (Academic Press, 2004), the book Intelligent Therapeutics: Biomimetic Systems and Nanotechnology in Drug Delivery (Elsevier, 2004) and his new monograph Nanotechnology in Therapeutics (Horizon Press, 2007). 

His pioneering contributions have received more than 28,000 citations making him one of the most cited chemical or biological scientists in the world and one of the three most cited biomedical engineers.  Of particular note is his lifetime effort to rationalize the design and development of biomaterials, drug delivery systems and medical devices. This has led to the development of the mathematical and physicochemical foundations of these fields including several theories and equations, widely used now in biomedical engineering. These include the Peppas equation (for the analysis of the abnormal and highly non-Fickian release and delivery of drugs, peptides and proteins from controlled release devices), the Peppas-Merrill equation (for the analysis of protein transport through biomedical membranes), the Brannon-Peppas theory (the first theory to analyze the behavior of intelligent, ionic gels in multicomponent biological fluids), the Huang-Peppas interpenetration theory of tethered structures across biological tissues, and the Peppas-Ritger correlation which has more than 1,000 citations in the last 15 years. His modeling, biomaterials, cellular and drug delivery research has been funded continuously since 1980 by NIH and since 1978 by NSF.

Dr. Peppas’ patents have been licensed or sublicensed to a number of pharmaceutical, chemical, biotechnology and medical device companies. A number of these companies were launched on the basis of these patent licenses. He served in numerous US government panels of NSF, NIH and other Federal Agencies. Among others he served in the Nanotechnology Technical Advisory Board to the President's Council of Advisors on Science and Technology from 2003-06.  In addition he has served as a member of the Advisory Boards of eleven companies and as a consultant of more than 60 companies, law firms and brokerage firms.

He has been recognized by more than 120 international awards. These include the highest research recognitions from the American Institute of Chemical Engineers (the 2006 William H. Walker Award, the 2006 Jay Bailey Biological Engineering Award, and the 2007 Institute Lecture, along with the 1994 Food, Pharmaceuticals and Bioengineering Award, the 1984 CME Stine Materials Engineering and Sciences Award, and the 1994 Best Paper Award of the AIChE Meeting), the highest research recognitions from the Society for Biomaterials (the 2005 Founders Award for life time contributions, and the 1992 Clemson Award for Basic Research), the highest recognitions of the American Association of Pharmaceutical Scientists (the 2002 Dale E. Wurster Award in Pharmaceutics, and the 1999 Research Achievement Award in Pharmaceutical Technology), the highest scientific recognitions of the Controlled Release Society (the 1991 Founders Award, the 2002 Eurand Award for Outstanding Contributions in Oral Drug Delivery, the 1999 J. Heller Award, and the 2003 Capsugel Award), the 1998 and 2003 Materials Research Society Best Paper Awards, the 1997 Whitaker Award from the International Society for Artificial Organs, the 2002 Newsmaker of the Year Award of the American Chemical Society, the 2002 Pioneer in Biomedical Engineering Award and the 1996 Whitaker Award from the IEEE Engineering in Medicine and Biology Society, and the 1995 APV Medal for Distinguished Pharmaceutical Contributions from the International Pharmaceutical Association. He has received the highest scientific recognitions from both Universities with which he has been associated (the 2007 Research Excellence Career Award and the 2004 Hamilton Best Paper Award from the University of Texas at Austin; and the 2002 Sigma Xi Award for Best Research and the 2000 Herbert  McCoy Research Award from Purdue University)

In 2006 Dr. Peppas was elected a member of the National Academy of Engineering, and the Academy of Medicine, Engineering and Science of Texas, and in 2005 a member of the Académie Nationale de Pharmacie (France). He is one of only two US chemical engineers to have been elected in this academy.  An international ambassador of chemical and biomedical engineering, he has received honorary doctorates from the Universities of Ghent (Belgium), Parma (Italy), and Athens (Greece).  In addition, he has been a Visiting Professor at the Universities of Geneva, Paris-Sud (Orsay), Parma, Pavia, Naples, Berlin (Free University), Santiago de Compostela, Complutense (Madrid), Hoshi (Tokyo), Hacettepe (Ankara), Athens, Hebrew (Jerusalem), Nanyang (Singapore) and California Institute of Technology. 

Dr. Peppas is the Chair of the College of Fellows of the American Institute of Medical and Biological Engineers (AIMBE), a Past-President of the Society for Biomaterials (2002-2003), a Past-President of the Controlled Release Society (1987-1988), and a past Director of the American Institute of Chemical Engineers (AIChE, 2000-2002). He was elected an inaugural Fellow of the Biomedical Engineering Society, a founding Fellow of AIMBE, a Fellow of the American Institute of Chemical Engineers, the American Physical Society, the Society for Biomaterials, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science, and an Honorary Member of the Italian Society for Natural Sciences and Medicine.

Peppas is also a recognized teacher and educator. He has supervised the theses of more than 130 graduate students and visiting scientists including 73 PhDs, of which 33 are now professors in other Universities.  He has also nurtured more than 470 undergraduates who have worked in his laboratory. Many of them have become leading biomedical scientists, engineers, physicians and medical professionals. For this reason, the American Association of Engineering Education has recognized him with all its major awards including the 2000 General Electric Senior Research Award recognizing the best engineering researcher of the USA, the 1992 George Westinghouse Award recognizing the best teacher, the 1988 Curtis McGraw Award for best engineering research under the age of 40, and the 2006 Dow Chemical Engineering award. He has also received numerous counselor and teaching awards, the latest being the 2007 Most Outstanding ChE Faculty Member Award.

He serves as a consulting editor of Pharmaceutical Research (2005- ), as the editor of the Elsevier Biomaterials Monograph Series and as an Associate Editor of the Cambridge University Press Biomedical Engineering Monograph Series. He has served as the editor of Advances in Chemical Engineering (1998-2003), Biomaterials (1982-2001), European Journal of Pharmaceutics and Biopharmaceutics  (1992-1995) and Elsevier Chemical Engineering Book Series (1985-1990). He sits on the editorial boards of numerous other journals.

Additional biographical information

Professor Nicholas A. Peppas is an active researcher in the fields of bionanotechnology, remote sensing, molecular recognition processes, controlled drug delivery, biomedical engineering, biomaterials, molecular modeling of protein structures in contact with biomaterials and tissues, and modeling of biomedical devices. Peppas is in charge of the Laboratory for Biomaterials, Drug Delivery, Bionanotechnology, and Molecular Recognition with 20 researchers (doctoral students, visiting scientists, technicians) and an annual budget of $2M.

Peppas was educated in chemical engineering at the National Technical University of Athens, Greece (Dipl.Eng., 1971) and at the Massachusetts Institute of Technology (Sc.D., 1973) and did postdoctoral work at the Arteriosclerosis Center of MIT. He joined Purdue University as an Assistant Professor of Chemical Engineering in 1976, and was promoted to Associate Professor in 1978 and Professor in 1982. From 1993 to 2002 he was the Showalter Distinguished Professor of Chemical and Biomedical Engineering at Purdue University in recognition of his research contributions to the fields of biomaterials, drug delivery, pharmaceutical technology, and biomedical engineering.

For these contributions, he received honorary doctorates from the University of Ghent, Belgium and the University of Parma, Italy, both in 1999, and from the University of Athens, Greece in 2000.

In addition to his main academic appointment, Professor Peppas has been active in international collaboration with major research centers around the world. He has served as a Visiting Professor at the University of Geneva, Switzerland (Fall 1982), the California Institute of Technology (Spring 1983), the University of Paris (Fall 1986), the Hacettepe University of Ankara, Turkey (November 1986), the University of Pavia, Italy  (May 1988), the University of Parma, Italy (Fall 1987 and Spring 1993), the Hoshi University of Tokyo, Japan (Springs 1994, 1995 and 1997), the Hebrew University of Jerusalem, Israel (Spring 1994), the University of Naples, Italy (May 1996), the University of Athens, Greece (Spring 2000), the Free University of Berlin, Germany (Spring 2001), the University of Santiago de Compostela, the Complutense University of Madrid, Spain (Spring 2001), and the Nanyang University of Singapore (May 2005).

Peppas’ administrative experience and contributions have been numerous and far-reaching. At UT Austin he serves as Director of the Laboratory for Biomaterials, Drug Delivery, Bionanotechnology, and Molecular Recognition. Since 2003 he has been also the Director of the NSF Program on Cellular and Molecular Imaging for Diagnostics and Therapeutics.

At Purdue he was the motive force behind the development of the Biomedical Engineering Program at Purdue (1995), and was successful in getting major Whitaker, NSF and NIH grants for the University. These grants helped in the establishment of the Department of Biomedical Engineering. Peppas was also instrumental in establishing a unique cross-disciplinary program in the broader field of Biomedical and Pharmaceutical Engineering, and Nanotechnology. In 1999 he founded and became the first Director (1999-2002) of the NSF Program on Therapeutic and Diagnostic Devices of Purdue University.

Peppas' research contributions have been in several areas of bionanotechnology, drug delivery, biomaterials, biomolecular engineering, mass transfer, kinetics and reaction engineering, polymer science and biomedical engineering. The multidisciplinary approach of his research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development. Physiologically-controlled and disease-responsive, feedback control-based devices require the operation/function of electrical and mechanical parts as a result of on-line measurement of physiological variables of the body, blood or other biological fluids. Peppas utilized the basics of biomedical transport phenomena, control theory, and kinetic behavior to design novel devices and to optimize their behavior in the body or in contact with the body. Adjustment of appropriate components of these devices was based on simple or sophisticated control or other physiological based models. Peppas and his group are in a unique position to be able to provide prototypes for direct medical testing. To that end, they have investigated the biocompatibility of all components of these devices and have provided knowledge of cellular response mechanisms that may be related to changes in immunological status, physical tissue damage. Research in physiologically-responsive devices has sought to show how it is possible to use classical and biomedical engineering principles, mathematics, transport phenomena and control theory to design devices and artificial organs, often based on "intelligent materials," which are responsive to changes in the surrounding environment. Peppas developed feedback control devices, such as glucose-sensitive microsensors that can respond to abnormal glucose levels by releasing incorporated insulin to the blood at desired rates. Such feedback control systems could be perfected for use in treatment of diabetes. In addition, he developed temperature-sensitive devices which can be used for treatment of malaria by release of antipyretics, etc.

Peppas is internationally known for his work on the preparation, characterization and evaluation of the behavior of compatible, crosslinked polymers known as hydrogels, which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. Peppas’ polymer research has examined fundamental aspects of the thermodynamics of polymer networks in contact with penetrants, the conformational changes of networks under load or in the presence of a diluent, the anomalous transport of penetrants in glassy polymers, and the kinetics of fast UV-polymerization reactions. In the field of controlled release, his group has provided the fundamental basis for a rational development of such systems. In addition, his work has led to a series of novel controlled release systems known as swelling controlled release systems, a series of pH-sensitive devices for drug delivery and a wide range of bio- and mucoadhesive systems. Other biomedical work of his group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, and understanding of the behavior of biomembranes.

His research has led to the development of a number of biomedical polymers and devices. For example, Peppas was the first to develop the freezing-thawing technique for preparation of novel poly(vinyl alcohol) gels in 1975. This technique led to a number of novel biomedical materials. His group pioneered the use of hydrogels in drug delivery applications, including epidermal bioadhesive systems and systems for the release of theophylline, proxyphylline, diltiazem, and oxprenolol. The first applications of this work were made public in 1979. Using intelligent polymers as early as 1984, Peppas and his group were the first to use such pH-sensitive and temperature-sensitive systems for modulated release of streptokinase and other fibrinolytic enzymes. His group has also developed novel buccal and vaginal controlled release devices.

More recently, his group has announced new inventions of oral insulin delivery systems and new biomaterials. More recently, his group has announced new inventions of oral insulin delivery systems and new biomaterials. These devices release insulin orally, “protecting” the insulin throughout its transport in the stomach, upper small intestine, and, eventually, blood, and bypassing diabetics’ need for several daily injections. Peppas’ group has shown that these new systems exhibit very high bioavailability. This is the first time that an oral system has been shown to be effective for oral delivery of proteins, especially insulin. In fact, the same technology has been used for the transmucosal (oral, buccal) delivery of calcitonin (for treatment of osteoporosis in postmenopausal women) and interferon-alpha (for cancer therapy). Finally, Peppas' group has invented new materials for hard, oxygen-permeable contact lenses, and for reconstruction of vocal cords.

He has been a member of numerous NSF, NIH and other federal panels and has served on various committees that have defined programmatic activities of the government. Among other committees he is presently a member of the Nanotechnology Technical Advisory Group of the President's Council of Advisors on Science and Technology.

Peppas is the author of 1,025 publications, 320 abstracts and 35 US and international patents. He is the coauthor or coeditor of 31 books and volumes, including the three-volume Hydrogels in Medicine and Pharmacy (CRC Press, 1987), the monograph Pulsatile Drug Delivery (Stuttgart, 1993), two books on Biopolymers (Springer, 1994) and the monograph Molecular and Cellular Foundations of Biomaterials (Academic Press, 2004). In addition, he has given more than 240 invited seminars and 880 scientific presentations in 32 countries.

Peppas is one of the most cited scientists with more than 28,000 citations. In the ISI survey of most cited authors in the world for the period 1981-1997, Peppas ranked first in citations among all biomedical scientists.

He is a consulting Editor of Pharmaceutical Research.  From 1998 to 2003 he was the editor of Advances in Chemical Engineering. From 1982 to 2001 he was the editor of the premier journal in his field, Biomaterials. From 1985 to 1990 he was also the editor of the Elsevier Chemical Engineering Book Series. He sits on the editorial boards of numerous other journals, including the Journal of Controlled Release, Nanomedicine, International Journal of Nanomedicine, Biomedical Nanodevices, Industrial Engineering Chemistry Research, Journal of Applied Polymer Science, Advanced Drug Delivery Reviews, Journal of Biomedical Materials Research, Journal of Biomaterials Science, Biomedical Materials, Tissue Engineering, Journal of Drug Delivery and Technology, and the European Journal of Pharmaceutics and Biopharmaceutics (where he served as US Editor from 1992 to 1995).

He has been active in various societies. Since 1975 he has been active in the Society for Biomaterials and served as its President (2003-04). Since 1981 he has been one of the leaders of the 2800-member Controlled Release Society. He guided it as its President in 1987-88, and organized the 1985 (Geneva) and 1993 (Washington) meetings of the Society as well as many other conferences and workshops. From 1994 to 1998 he chaired the Global Networks Committee of CRS, which was responsible for the organization of active controlled release societies in the United Kingdom, Germany, Italy, Spain/Portugal, Greece, Israel, Thailand, Korea, China, Taiwan and Argentina.

In addition he has been very active in the American Institute of Chemical Engineers, where he was a Director (1999-2002), the 1988-90 Chairman of its 1500-member Materials Division and a Director of the Food, Pharmaceuticals and Bioengineering Division. He is also a member of the American Physical Society, American Chemical Society, New York Academy of Sciences, Materials Research Society, American Association of Pharmaceutical Scientists, Biomedical Engineering Society, Tissue Engineering Society, North American Membrane Society, American Society for Engineering Education, American Association for the Advancement of Sciences, Sigma Xi, and Phi Kappa Phi.

He has been recognized by various awards including the 2007 Institute Lecture of AIChE, the 2007 Carreer Research Excellence Award of the University of Texas, the 2007 Most Outstanding ChE Faculty Member by the Engineering Student Council of the University of Texas, the 2006 Jay Bailey Award of the Biological Engineering Society of AIChE,  the 2006 William H. Walker Award of AIChE, the 2006 Best Paper Award of the European Controlled Release Meeting, the 2006 Dow Chemical Engineering and Lctureship Award of the American Society for Engineering Education, the 2005 Best Paper Award of the International Microencapsulation Society, the 2005 Distinguished Scientist Award of the Houston Society of Engineering in Medicine and Biology, the 2005 Founders Award of the Society for Biomaterials, the 2005 Whitaker Graduate Student Award of the Society for Biomaterials, the 2004 Research Excellence Award for Best Research Paper of the  University of Texas, the 2003 Materials Research Society Graduate Research Award, the 2003 Capsugel Award for Best Graduate Student Research in Controlled Drug Delivery, the 2003 Nagai Foundation Award for Research, the 2002 Dale E. Wurster Award in Pharmaceutics of the American Association of Pharmaceutical Scientists, the 2002 Graduate Student Award for Outstanding Research of the Biomedical Engineering Society, the 2002 Newsmaker of the Year of the American Chemical Society, the 2002 Graduate Student Award of the IEEE Engineering in Medicine and Biology Society, the 2002 Eurand Award for Outstanding Contributions in Oral Drug Delivery of the Controlled Release Society, the 2002 recognition as a Pioneer in Biomedical Engineering from the IEEE Engineering in Medicine and Biology Society, the 2002 Sigma Xi Award for Best Research at Purdue University, the 2002 Chorafas Foundation Award for Best Dissertation, the 2002 Best Graduate Student Paper Award of the Materials Research Society, the 2000 General Electric Senior Research Award of ASEE recognizing the best engineering researcher of the USA, the 2000 Herbert McCoy Award for exceptional research by Purdue University, the 2000 APV Best Paper Award, the 2000 APV Best thesis in the Pharmaceutical Sciences Award, 1999 Research Achievement Award in Pharmaceutical Technology of AAPS, the 1995 APV-International Pharmaceutical Technology Medal, the 1994 Pharmaceutical and Bioengineering Award of AIChE, the 1992 Clemson Award for Basic Research of the Society for Biomaterials, the 1992 George Westinghouse Award of ASEE, the 1991 Founders Award for Outstanding Research from the Controlled Release Society, the 1988 Curtis McGraw Award of ASEE for best engineering research under the age of 40, the 1984 Materials Engineering and Sciences Award of AIChE. Also he and his students have received several "best paper" awards including the 1999 AAPS Award, the 1998 Materials Research Society Award, the 1994 Best Paper Award of the Annual AIChE Meeting.

He has given numerous distinguished lectureships including the Plenary Lectureships of the National Biotechnology Conference of AAPS (San Diego, 2007), the 9th Greek Scientific Chemical Engineering Conference (Athens, 2007), the 31st Annual Meeting of the Society for Biomaterials (Chicago, 2007), the Pharmaceutical Sciences World Congress (Amsterdam, 2007), the Dow Distinguished Lectureship, American Society for Engineering Education (Chicago, 2006), the 3rd World Congress on Biomimetics, Artificial Muscles & Bionanotechnology (Lausanne, 2006), the European Polymer Congress (Moscow, 2005), the Society for Biomaterials Meeting (Memphis, 2005), the Third World Congress on Drug Absorption, Transport and Delivery (Barcelona, 2005), the American Institute of Medical and Biological Engineering (Washington, 2004), the European Materials Research Society Meeting (Warsaw, 2004), the 20th Japanese Drug Delivery Systems Meeting (Tokyo, 2004), the Gattefossé Lecturer Meeting (Lyon, 2004), the NIH/NSF Transport in Biological Systems Panel (Washington, 2004), the NIH/NSF Bionanotechnology Panel (Washington, 2003), the 4th Annual BioMEMS and NanoTech meeting (Washington, 2003), the Gattefossé Lecture (St. Rémy, 2003), the Harry G. Fair Distinguished Lecture (University of Oklahoma 2003), the Larson-Ruth Distinguished Lecture (Iowa State University, 2003), the Biomedical Engineering Society Meeting, (Houston, 2003), the ACS Meeting (Boston, 2002), the International Pharmaceutical Technology Symposium (Istanbul, 2002), the 29th International Symposium of Controlled Release of Bioactive Agents (Seoul, 2002), the Particles International Conference (Orlando, 2002), the Third World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, (Florence, 2002), the 6th International Symposium on Polymers for Advanced Technologies (Eilat, 2001), the North American Membrane Society Meeting (Boulder, 2000), the 6th World Congress of Biomaterials (Hawaii, 2000), the Symposium on Biomedical Polymers for the 21st Century (Boston, 2000), the Drug Delivery in the Third Millennium Meeting (Pisa, 1999), Third Central European Symposium on Pharmaceutical Technology (Portoroz, 1999), American Institute of Chemical Engineers Meeting (Miami, 1998), International Pharmaceutical conference (1998), Materials Research Society Meeting (Boston, 1993), the Fourth World Congress of Biomaterials (Berlin, 1992), the Fourth International Conference on Pharmaceutical Technology (Paris, 1986) and the Annual Meetings of the Italian (1990) and Danish (1986) Chemical Societies, the Merck Distinguished Lectureship (Rutgers University, 2002), the Bayer Lectureship (University of Pittsburgh, 2000), the Minnetonka Lectureship (University of Minnesota, 1988), the Warren McCabe Lectureship (North Carolina State University, 1987) and others.

Peppas has been elected a Founding Fellow of the American Institute of Medical and Biological Engineering (1993), an Inaugural Fellow of the Biomedical Engineering Society (2005), a Fellow of the American Association of the Advancement of Science (2000), a Fellow of the American Physical Society (1997), a Fellow of the American Institute of Chemical Engineers (1997), a Fellow of the Society for Biomaterials (1994), a Fellow of the American Association of Pharmaceutical Scientists (1993) and an Honorary Member of the Italian Society of Medicine and Natural Sciences (1996). In 1991 he was named a Polymer Pioneer by Polymer News. In 2002 he was named a Pioneer in Biomedical Engineering by the IEEE Engineering in Medicine and Biology Society

Peppas has supervised the theses of 73 Ph.D. students, including 33 current professors in other Universities, and another 67 students and 24 postdoctoral fellows and visiting scientists. His former students include many industrial leaders in chemical, pharmaceutical or medical companies.

Peppas has been active in teaching and counseling. For his teaching, he has received the George Westinghouse (1992) and the Western Electric Fund Teaching Award (1980) from ASEE, the A.A. Potter Best Engineering Teacher Award of Purdue University (in 1978, 1985, and 1994; only faculty member to have achieved this honor three times), the R.N. Shreve Chemical Engineering Teaching Award of Purdue University (1978, 1980, 1982, 1985, 1988 and 1994); and the Most Outstanding ChE Faculty Member by the Engineering Student Council of the University of Texas (2007). For counseling he has received the 1992 AIChE Best Counselor Award and the Marion B. Scott Award of Purdue University (1999).

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